Disease Screening

FAQ's about Estek
What is a disease screening Score ? 

The intention of disease screening test or disease trend, is to identify the possibility of disease or disorder without symptoms. The screening score of a disease/disorder is related to the statistical analysis of the specificity and sensitivity of the markers related to the disease or disorder.

The screening score should be used to indicate the need for further evaluation – not as a basic for diagnosis


How the screening Score is used?


The  negative further evaluation results (subclinical means not detected by the conventional tests) of a screening score positive will allow the preventive medicine and  time when lifestyle intervention may  be useful therapy.

The negative further evaluation results (subclinical means not detected by the conventional tests) of a screening score positive will allow the preventive medicine and time when lifestyle intervention may be useful therapy


Health Care Software Solution New approach of the Diseases Screening: The Diseases Screening Score 



The Essential Hypertension Causes: New concept and validation 

Arterial stiffness is increasingly recognized as an importantprognostic index and potential therapeutic target in patientswith hypertension. It is closely linked to, but by no meanssynonymous with, raised blood pressure, and its physiopathologyis still not fully understood. Aortic stiffness and arterialpulse wave reflections are key determinants of elevated centralsystolic pressure and are associated with adverse cardiovascularoutcomes, independent of blood pressure. Indeed, the 2003 EuropeanSociety of Hypertension guidelines on the management of hypertensionacknowledge the potential role of arterial stiffness measurementin clinical management1 and have prompted the publication ofa consensus document on the measurement of central blood pressureand hemodynamics.2 A detailed expert consensus document hasalso been published on the methodologic and clinical issuesaround arterial stiffness.3 Broader implementation of thesetechniques into routine care seems inevitable. 

1. European Society of Hypertension-European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 2003; 21: 1011–1053.

2. Agabiti-Rosei E, Mancia G, O'Rourke MF, Roman MJ, Safar ME, Smulyan H, Wang JG, Wilkinson IB, Williams B, Vlachopoulos C. Central blood pressure measurements and antihypertensive therapy: a consensus document. Hypertension. 2007; 50: 154–160.

3 Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27: 2588–2605.

The Cardiac output measurement requirement in the hypertension treatment 

Diseases of the cardiovascular system are often associated with changes in hemodynamic indicators and in particular the cardiac output (Q) with the pandemic diseases of hypertension and heart failure. Cardiovascular disease can be associated with increased Q as occurs during infection and sepsis, or decreased Q, as in cardiomyopathy and heart failure. The ability to accurately measure Q is important in clinical medicine as it provides for improved diagnosis of abnormalities, and can be used to guide appropriate therapeutic management. 

Q measurement, if it were accurate and non-invasive, would be adopted as part of every clinical examination from general observations to the intensive care ward, and would be as common as simple blood pressure measurements are now. Such practice, if it were adopted, may revolutionize the treatment of many cardiovascular diseases including hypertension and heart failure.

Insulin resistance is linked to a range of cardiovascular risk factors
Insulin resistance is closely linked to a number of cardiovascular risk factors, collectively known as the Metabolic Syndrome or Insulin Resistance Syndrome. Components of the Metabolic Syndrome include well known cardiovascular risk factors such as hyperglycemia, dyslipidemia and hypertension. Additional cardiovascular risk factors, that is damage to blood vessels (endothelial dysfunction), clotting abnormalities (hypofibrinolysis) and inflammation, have also been recognized as key components of the Metabolic Syndrome.

Together, the cluster of cardiovascular risk factors that make up the Metabolic Syndrome significantly increases the risk of atherosclerosis.



Early diagnosis requirement 

As regard to the treatment plan challenge , early diagnosis of diseases with fast and non invasive techniques may identify persons at riskat a time when lifestyle intervention may be useful therapy.

Also, It may be useful to identify the risk before the development of complications related to the diseases network and to the drugs interactions and side effects.


ES Complex versus EKG and Echocardiogram 

Unlike the EKG will diagnose heart damage , size and position of the chambers ,the echocardiogram will study the appearance and function of the heart valves the ES Oxy will allow early diagnosis of arterial stiffnesswith noninvasive techniques before the development of hypertension or cardiovascular complications and may identify persons at risk at a time when lifestyle intervention may be useful therapy.

Invasive methods are well accepted, but there is increasing evidence that these methods are neither accurate nor effective in guiding therapy, so there is an increasing focus on development of non-invasive methods. The accepted gold standard is the non invasive measurement is the thoracic impedance . The problem is the cost and time of the examination


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